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*Correspondence: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

This article reviews the utility of monoamine oxidase inhibitors (MAOIs) for difficult-to-treat MDD and, in particular, a newer transdermal formulation, which may be a safe and better-tolerated option than oral MAOIs.2 METHOD This critical review of the literature focused on MAOI therapy and difficult-to-treat forms of depression

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The therapeutic efficacy of the internalization mechanism is rooted in the mitochondrias ability to produce ATP, while the non-internalization mechanism is based on the idea that mitochondria can interact with specific substances on the cell surface to transmit information and stimulate cellular self-preservation (188, 189)